Interaction Between Sex and Organic Anion‐Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib‐N‐Oxide and Regorafenib‐Glucuronide in Mice

Regorafenib, a multikinase inhibitor used in the treatment of various solid tumors, undergoes extensive uridine 5′‐diphosphate glucuronosyltransferase (Ugt)1a9‐mediated glucuronidation to form regorafenib‐N‐β‐glucuronide (M7; RG), but the contribution of hepatic uptake transporters, such as organic...

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Detalles Bibliográficos
Autores principales: Fu, Qiang, Chen, Mingqing, Anderson, Jason T., Sun, Xinxin, Hu, Shuiying, Sparreboom, Alex, Baker, Sharyn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662550/
https://www.ncbi.nlm.nih.gov/pubmed/30955241
http://dx.doi.org/10.1111/cts.12630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662550/
https://www.ncbi.nlm.nih.gov/pubmed/30955241
http://dx.doi.org/10.1111/cts.12630

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