The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria.

Controlling cellular processes with light can help elucidate their underlying mechanisms. Here we present ZAPALOG, a small-molecule dimerizer that undergoes photolysis when exposed to blue light. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes...

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Detalles Bibliográficos
Autores principales: Gutnick, Amos, Banghart, Matthew R., West, Emma R., Schwarz, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662610/
https://www.ncbi.nlm.nih.gov/pubmed/31061466
http://dx.doi.org/10.1038/s41556-019-0317-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662610/
https://www.ncbi.nlm.nih.gov/pubmed/31061466
http://dx.doi.org/10.1038/s41556-019-0317-2

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