α-Synuclein pathology spread through the brain connectome is modulated by selective vulnerability and predicted by network analysis

Studies of patients afflicted by neurodegenerative diseases suggest that misfolded proteins spread through the brain along anatomically-connected networks, prompting progressive decline. Recently, mouse models have recapitulated the cell-to-cell transmission of pathogenic proteins and neuron death o...

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Detalles Bibliográficos
Autores principales: Henderson, Michael X., Cornblath, Eli J., Darwich, Adam, Zhang, Bin, Brown, Hannah, Gathagan, Ronald J., Sandler, Raizel M., Bassett, Danielle S., Trojanowski, John Q., Lee, Virginia M.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662627/
https://www.ncbi.nlm.nih.gov/pubmed/31346295
http://dx.doi.org/10.1038/s41593-019-0457-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662627/
https://www.ncbi.nlm.nih.gov/pubmed/31346295
http://dx.doi.org/10.1038/s41593-019-0457-5

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