Cargando…

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs

The nuclear exosome and its essential co-factor, the RNA helicase MTR4, play crucial roles in several RNA degradation pathways. Besides unwinding RNA substrates for exosome-mediated degradation, MTR4 associates with RNA-binding proteins that function as adaptors in different RNA processing and decay...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lingaraju, Mahesh, Johnsen, Dennis, Schlundt, Andreas, Langer, Lukas M., Basquin, Jérôme, Sattler, Michael, Heick Jensen, Torben, Falk, Sebastian, Conti, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662825/ https://www.ncbi.nlm.nih.gov/pubmed/31358741 http://dx.doi.org/10.1038/s41467-019-11339-x

Ejemplares similares

Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53
por: Falk, Sebastian, et al.
Publicado: (2017)

Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome
por: Gerlach, Piotr, et al.
Publicado: (2022)

Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase
por: Falk, Sebastian, et al.
Publicado: (2017)

Genetic interactions suggest multiple distinct roles of the arch and core helicase domains of Mtr4 in Rrp6 and exosome function
por: Klauer, A. Alejandra, et al.
Publicado: (2013)

Structural basis for MTR4–ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex
por: Puno, M. Rhyan, et al.
Publicado: (2018)

Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase
por: Wasmuth, Elizabeth V, et al.
Publicado: (2017)

Structure of a SMG8–SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins
por: Li, Liang, et al.
Publicado: (2017)

NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction
por: Wang, Jianshu, et al.
Publicado: (2019)

In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae
por: Sterrett, Maria C, et al.
Publicado: (2023)

The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts
por: Silla, Toomas, et al.
Publicado: (2018)

The RNA Helicases AtMTR4 and HEN2 Target Specific Subsets of Nuclear Transcripts for Degradation by the Nuclear Exosome in Arabidopsis thaliana
por: Lange, Heike, et al.
Publicado: (2014)

Methods to assess helicase and translocation activities of human nuclear RNA exosome and RNA adaptor complexes
por: Puno, M. Rhyan, et al.
Publicado: (2022)

The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding
por: Taylor, Lacy L., et al.
Publicado: (2014)

A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment
por: Bui, Huyen T., et al.
Publicado: (2012)

RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes
por: Yu, Lili, et al.
Publicado: (2022)

Distinct and evolutionary conserved structural features of the human nuclear exosome complex
por: Gerlach, Piotr, et al.
Publicado: (2018)

Hydrogen-deuterium exchange mass spectrometry of Mtr4 with diverse RNAs reveals substrate-dependent dynamics and interfaces in the arch
por: Zhang, Naifu, et al.
Publicado: (2022)

The RNA helicases Dbp2 and Mtr4 regulate the expression of Xrn1-sensitive long non-coding RNAs in yeast
por: Wery, Maxime, et al.
Publicado: (2023)

The MTN and MTR bending magnets
por: Keizer, Reinder L, et al.
Publicado: (1978)

Sen1 has unique structural features grafted on the architecture of the Upf1‐like helicase family
por: Leonaitė, Bronislava, et al.
Publicado: (2017)

Computational identification of signals predictive for nuclear RNA exosome degradation pathway targeting
por: Wu, Mengjun, et al.
Publicado: (2022)

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers
por: Kozer, Noga, et al.
Publicado: (2014)

A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation
por: Molleston, Jerome M., et al.
Publicado: (2016)

Correction for Jiang et al., Kinetics of trifurcated electron flow in the decaheme bacterial proteins MtrC and MtrF
Publicado: (2022)

Structure and mechanism of the methyltransferase ribozyme MTR1
por: Scheitl, Carolin P.M., et al.
Publicado: (2022)

The Role of ADP-ribosylation Factor and Phospholipase D in Adaptor Recruitment
por: West, Michele A., et al.
Publicado: (1997)

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport
por: Canty, John T., et al.
Publicado: (2023)

The putative RNase P motif in the DEAD box helicase Hera is dispensable for efficient interaction with RNA and helicase activity
por: Linden, Martin H., et al.
Publicado: (2008)

Trypanosome MTR4 is involved in rRNA processing
por: Cristodero, Marina, et al.
Publicado: (2007)

Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
por: Zalucki, Yaramah M., et al.
Publicado: (2012)

Regulation and Function of the CD3γ DxxxLL Motif: A Binding Site for Adaptor Protein-1 and Adaptor Protein-2 in Vitro
por: Dietrich, Jes, et al.
Publicado: (1997)

Air2p is critical for the assembly and RNA-binding of the TRAMP complex and the KOW domain of Mtr4p is crucial for exosome activation
por: Holub, Peter, et al.
Publicado: (2012)

Development of a Hyperosmotic Stress Inducible Gene Expression System by Engineering the MtrA/MtrB-Dependent NCgl1418 Promoter in Corynebacterium glutamicum
por: Huang, Jingwen, et al.
Publicado: (2021)

Certain Adenylated Non-Coding RNAs, Including 5′ Leader Sequences of Primary MicroRNA Transcripts, Accumulate in Mouse Cells following Depletion of the RNA Helicase MTR4
por: Dorweiler, Jane E., et al.
Publicado: (2014)

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
por: van Wietmarschen, Niek, et al.
Publicado: (2018)

Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
por: Falk, Sebastian, et al.
Publicado: (2016)

Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites
por: Bean, Björn D.M., et al.
Publicado: (2018)

Modulation of the Neisseria gonorrhoeae drug efflux conduit MtrE
por: Tamburrino, Giulia, et al.
Publicado: (2017)

Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells
por: Darowski, Diana, et al.
Publicado: (2019)

1440. The Genetic Basis for a Neisseria gonorrhoeae Clinical Isolate That Contains mtrR(-79) Mutation But Is Highly Susceptible to Antibiotics Effluxed by the Mtr Pump System
por: Huang, Jianzhong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rjl51tlk98eb2hh3dd7d2oah89