In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia

The therapeutic effect of in vivo direct reprogramming on ischemic stroke has not been evaluated. In the present study, a retroviral solution (1.5–2.0 × 10(7) /ul) of mock pMX-GFP (n = 13) or pMX-Ascl1/Sox2/NeuroD1 (ASN) (n = 14) was directly injected into the ipsilateral striatum and cortex 3 days...

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Detalles Bibliográficos
Autores principales: Yamashita, Toru, Shang, Jingwei, Nakano, Yumiko, Morihara, Ryuta, Sato, Kota, Takemoto, Mami, Hishikawa, Nozomi, Ohta, Yasuyuki, Abe, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662847/
https://www.ncbi.nlm.nih.gov/pubmed/31358888
http://dx.doi.org/10.1038/s41598-019-47482-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662847/
https://www.ncbi.nlm.nih.gov/pubmed/31358888
http://dx.doi.org/10.1038/s41598-019-47482-0

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