Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer’s disease

Lipid metabolism is abnormal in Alzheimer’s disease (AD) brain leading to ceramide and sphingosine accumulation and reduced levels of brain sphingosine-1-phosphate (S1P). We hypothesize that changes in S1P signaling are central to the inflammatory and immune-pathogenesis of AD and the therapeutic be...

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Detalles Bibliográficos
Autores principales: Carreras, Isabel, Aytan, Nurgul, Choi, Ji-Kyung, Tognoni, Christina M., Kowall, Neil W., Jenkins, Bruce G., Dedeoglu, Alpaslan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662857/
https://www.ncbi.nlm.nih.gov/pubmed/31358793
http://dx.doi.org/10.1038/s41598-019-47287-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662857/
https://www.ncbi.nlm.nih.gov/pubmed/31358793
http://dx.doi.org/10.1038/s41598-019-47287-1

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