Mitochondrial dysfunction causes Ca(2+) overload and ECM degradation–mediated muscle damage in C. elegans

Mitochondrial dysfunction impairs muscle health and causes subsequent muscle wasting. This study explores the role of mitochondrial dysfunction as an intramuscular signal for the extracellular matrix (ECM)–based proteolysis and, consequentially, muscle cell dystrophy. We found that inhibition of the...

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Detalles Bibliográficos
Autores principales: Sudevan, Surabhi, Takiura, Mai, Kubota, Yukihiko, Higashitani, Nahoko, Cooke, Michael, Ellwood, Rebecca A., Etheridge, Timothy, Szewczyk, Nathaniel J., Higashitani, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662967/
https://www.ncbi.nlm.nih.gov/pubmed/31162948
http://dx.doi.org/10.1096/fj.201802298R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662967/
https://www.ncbi.nlm.nih.gov/pubmed/31162948
http://dx.doi.org/10.1096/fj.201802298R

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