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Mitochondrial dysfunction causes Ca(2+) overload and ECM degradation–mediated muscle damage in C. elegans
Mitochondrial dysfunction impairs muscle health and causes subsequent muscle wasting. This study explores the role of mitochondrial dysfunction as an intramuscular signal for the extracellular matrix (ECM)–based proteolysis and, consequentially, muscle cell dystrophy. We found that inhibition of the...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Federation of American Societies for Experimental Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662967/ https://www.ncbi.nlm.nih.gov/pubmed/31162948 http://dx.doi.org/10.1096/fj.201802298R |