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The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)
BACKGROUND: Apolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-ε4 allele has long been associated with increased risks of Alzheimer's disease and mortality, but the effect of the less prevalent APOE-ε2 allele on diseases in the elde...
Autores principales: | Wolters, Frank J., Yang, Qiong, Biggs, Mary L., Jakobsdottir, Johanna, Li, Shuo, Evans, Daniel S., Bis, Joshua C., Harris, Tamara B., Vasan, Ramachandran S., Zilhao, Nuno R., Ghanbari, Mohsen, Ikram, M. Arfan, Launer, Lenore, Psaty, Bruce M., Tranah, Gregory J., Kulminski, Alexander M., Gudnason, Vilmundur, Seshadri, Sudha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663005/ https://www.ncbi.nlm.nih.gov/pubmed/31356640 http://dx.doi.org/10.1371/journal.pone.0219668 |
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