A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability

Neurons are sensitive to changes in the dosage of many genes, especially those regulating synaptic functions. Haploinsufficiency of SHANK3 causes Phelan-McDermid syndrome and autism, whereas duplication of the same gene leads to SHANK3 duplication syndrome, a disorder characterized by neuropsychiatr...

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Detalles Bibliográficos
Autores principales: Wang, Li, Adamski, Carolyn J., Bondar, Vitaliy V, Craigen, Evelyn, Collette, John R., Pang, Kaifang, Han, Kihoon, Liu, Zhandong, Sifers, Richard N., Holder, J. Lloyd, Zoghbi, Huda Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663662/
https://www.ncbi.nlm.nih.gov/pubmed/30696942
http://dx.doi.org/10.1038/s41380-018-0325-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663662/
https://www.ncbi.nlm.nih.gov/pubmed/30696942
http://dx.doi.org/10.1038/s41380-018-0325-9

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