Cargando…

Targeting the Synapse in Alzheimer’s Disease

Dynamic gain and loss of synapses is fundamental to healthy brain function. While Alzheimer’s Disease (AD) treatment strategies have largely focussed on beta-amyloid and tau protein pathologies, the synapse itself may also be a critical endpoint to consider regarding disease modification. Disruption...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jackson, Johanna, Jambrina, Enrique, Li, Jennifer, Marston, Hugh, Menzies, Fiona, Phillips, Keith, Gilmour, Gary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664030/ https://www.ncbi.nlm.nih.gov/pubmed/31396031 http://dx.doi.org/10.3389/fnins.2019.00735

Ejemplares similares

Synapses, Microglia, and Lipids in Alzheimer’s Disease
por: Paasila, Patrick J., et al.
Publicado: (2022)

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
por: Guerrero-Muñoz, Marcos J., et al.
Publicado: (2015)

Synapses, Synaptic Activity and Intraneuronal Aβ in Alzheimer's Disease
por: Tampellini, Davide, et al.
Publicado: (2010)

Commentary: APP as a Mediator of the Synapse Pathology in Alzheimer's Disease
por: Schreurs, An, et al.
Publicado: (2018)

Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression
por: Meftah, Soraya, et al.
Publicado: (2023)

The Role of Glial Cells and Synapse Loss in Mouse Models of Alzheimer’s Disease
por: Ziegler-Waldkirch, Stephanie, et al.
Publicado: (2018)

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease
por: Jones, Megan E., et al.
Publicado: (2023)

Targeting Microglia-Synapse Interactions in Alzheimer’s Disease
por: Piccioni, Gaia, et al.
Publicado: (2021)

The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review
por: Hulshof, Lianne A., et al.
Publicado: (2022)

The Role of Mesenchymal Stem Cells in Regulating Astrocytes-Related Synapse Dysfunction in Early Alzheimer’s Disease
por: Liu, Cong
Publicado: (2022)

Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer's Disease
por: Yu, Wendou, et al.
Publicado: (2012)

Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease
por: Liu, Cai-Yun, et al.
Publicado: (2018)

Single-synapse analyses of Alzheimer’s disease implicate pathologic tau, DJ1, CD47, and ApoE
por: Phongpreecha, Thanaphong, et al.
Publicado: (2021)

Revisiting I-BAR Proteins at Central Synapses
por: Chatzi, Christina, et al.
Publicado: (2021)

Synapse-Specific Regulation Revealed at Single Synapses Is Concealed When Recording Multiple Synapses
por: Lines, Justin, et al.
Publicado: (2017)

Excitation Control: Balancing PSD-95 Function at the Synapse
por: Keith, Dove, et al.
Publicado: (2008)

Oxygen responses within the nucleus accumbens are associated with individual differences in effort exertion in rats
por: Hailwood, Jonathan M., et al.
Publicado: (2018)

Recycling at synapses
por: Gross, Owen P, et al.
Publicado: (2016)

Huntingtin and the Synapse
por: Barron, Jessica C., et al.
Publicado: (2021)

The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
por: Tang, Chuan, et al.
Publicado: (2022)

Electron microscopy analysis of astrocyte-synapse interactions shows altered dynamics in an Alzheimer’s disease mouse model
por: Kater, Mandy S. J., et al.
Publicado: (2023)

The Stability of Glutamatergic Synapses Is Independent of Activity Level, but Predicted by Synapse Size
por: Quinn, Dylan P., et al.
Publicado: (2019)

The Synapse Diversity Dilemma: Molecular Heterogeneity Confounds Studies of Synapse Function
por: Grant, Seth G. N., et al.
Publicado: (2020)

Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide hormones and novel receptor agonists protect synapses in Alzheimer’s and Parkinson’s diseases
por: Hölscher, Christian
Publicado: (2022)

Alzheimer's disease: synapses gone cold
por: Koffie, Robert M, et al.
Publicado: (2011)

Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
por: Hemonnot, Anne-Laure, et al.
Publicado: (2019)

Evidence for deficits in behavioural and physiological responses in aged mice relevant to the psychiatric symptom of apathy
por: Jackson, Megan G., et al.
Publicado: (2021)

Editorial: Activated Synapses
por: Rubio, F. Javier, et al.
Publicado: (2022)

Glial Control of Synapse Number in Healthy and Diseased Brain
por: Lee, Eunbeol, et al.
Publicado: (2019)

Neuroglial Plasticity at Striatal Glutamatergic Synapses in Parkinson's Disease
por: Villalba, Rosa M., et al.
Publicado: (2011)

Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases
por: Di Paolo, Andres, et al.
Publicado: (2021)

miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1
por: Ross, Sean P., et al.
Publicado: (2018)

Fully-Automatic Synapse Prediction and Validation on a Large Data Set
por: Huang, Gary B., et al.
Publicado: (2018)

Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmission
por: Reese, Austin L, et al.
Publicado: (2016)

The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus
por: Martin, E Anne, et al.
Publicado: (2015)

Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities
por: Liu, Jie, et al.
Publicado: (2019)

Pyroptosis as a candidate therapeutic target for Alzheimer’s disease
por: Huang, Yuehua, et al.
Publicado: (2022)

Morphological changes of glutamatergic synapses in animal models of Parkinson’s disease
por: Villalba, Rosa M., et al.
Publicado: (2015)

Building up the inhibitory synapse
por: Cherubini, Enrico, et al.
Publicado: (2013)

Neuronal epigenetics and the aging synapse
por: Azpurua, Jorge, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5pgtcfhnmg6502fl35cbism7c3