Systemic L-Buthionine -S-R-Sulfoximine Treatment Increases Plasma NGF and Upregulates L-cys/L-cys2 Transporter and γ-Glutamylcysteine Ligase mRNAs Through the NGF/TrkA/Akt/Nrf2 Pathway in the Striatum

Glutathione (GSH) is the most abundant intracellular antioxidant. GSH depletion leads to oxidative stress and neuronal damage in the central nervous system (CNS). In mice, the acute systemic inhibition of GSH synthesis by L-buthionine-S-R-sulfoximine (BSO) triggers a protective response and a subseq...

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Detalles Bibliográficos
Autores principales: Valdovinos-Flores, Cesar, Limón-Pacheco, Jorge H., León-Rodríguez, Renato, Petrosyan, Pavel, Garza-Lombó, Carla, Gonsebatt, Maria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664075/
https://www.ncbi.nlm.nih.gov/pubmed/31396052
http://dx.doi.org/10.3389/fncel.2019.00325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664075/
https://www.ncbi.nlm.nih.gov/pubmed/31396052
http://dx.doi.org/10.3389/fncel.2019.00325

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