A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis

Whole-genome doubling (WGD) is common early in tumorigenesis. WGD doubles ploidy and centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division. To survive, cells must cluster centrosomes to allow bipolar cell division. Can...

Descripción completa

Detalles Bibliográficos
Autores principales: Antao, Noelle V., Marcet-Ortega, Marina, Cifani, Paolo, Kentsis, Alex, Foley, Emily A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664223/
https://www.ncbi.nlm.nih.gov/pubmed/31357169
http://dx.doi.org/10.1016/j.isci.2019.07.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664223/
https://www.ncbi.nlm.nih.gov/pubmed/31357169
http://dx.doi.org/10.1016/j.isci.2019.07.018

Ejemplares similares