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A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis
Whole-genome doubling (WGD) is common early in tumorigenesis. WGD doubles ploidy and centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division. To survive, cells must cluster centrosomes to allow bipolar cell division. Can...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664223/ https://www.ncbi.nlm.nih.gov/pubmed/31357169 http://dx.doi.org/10.1016/j.isci.2019.07.018 |