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High temperature suppressed SSC self-renewal through S phase cell cycle arrest but not apoptosis

BACKGROUND: High temperature has a very adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility through either apoptosis or DNA damage. However, the direct effects of heat stress on the development of spermatogonial stem cells (SSCs) are still unknown because SSCs are...

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Detalles Bibliográficos
Autores principales: Wang, Jia, Gao, Wei-Jun, Deng, Shou-Long, Liu, Xiang, Jia, Hua, Ma, Wen-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664773/
https://www.ncbi.nlm.nih.gov/pubmed/31358059
http://dx.doi.org/10.1186/s13287-019-1335-5