Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif

One of the primary targets of immune checkpoint inhibition is the negative immune regulatory molecule CTLA-4. Immune-related adverse events are commonly observed following CTLA-4 inhibition in melanoma treatment, and a spectrum of these conditions are also observed in individuals with germline haplo...

Descripción completa

Detalles Bibliográficos
Autores principales: Siggs, Owen M., Russell, Amanda, Singh-Grewal, Davinder, Wong, Melanie, Chan, Pearl, Craig, Maria E., O'Loughlin, Ted, Stormon, Michael, Goodnow, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664875/
https://www.ncbi.nlm.nih.gov/pubmed/31396201
http://dx.doi.org/10.3389/fimmu.2019.01544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664875/
https://www.ncbi.nlm.nih.gov/pubmed/31396201
http://dx.doi.org/10.3389/fimmu.2019.01544

Ejemplares similares