The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1

Although mesenchymal stromal cells (MSCs) are among the most promising cell sources for cell-based therapies and regenerative medicine, the decline in their function with age due to cellular senescence limits their therapeutic applications. Unveiling the underlying mechanism of MSC senescence is the...

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Detalles Bibliográficos
Autores principales: Lee, Hyang Ju, Choi, Bongkun, Kim, Yongsub, Lee, Sang Eun, Jin, Hye Jin, Lee, Hee-Seop, Chang, Eun-Ju, Kim, Seong Who
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665952/
https://www.ncbi.nlm.nih.gov/pubmed/31396213
http://dx.doi.org/10.3389/fimmu.2019.01659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665952/
https://www.ncbi.nlm.nih.gov/pubmed/31396213
http://dx.doi.org/10.3389/fimmu.2019.01659

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