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The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1

Although mesenchymal stromal cells (MSCs) are among the most promising cell sources for cell-based therapies and regenerative medicine, the decline in their function with age due to cellular senescence limits their therapeutic applications. Unveiling the underlying mechanism of MSC senescence is the...

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Detalles Bibliográficos
Autores principales:	Lee, Hyang Ju, Choi, Bongkun, Kim, Yongsub, Lee, Sang Eun, Jin, Hye Jin, Lee, Hee-Seop, Chang, Eun-Ju, Kim, Seong Who
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665952/ https://www.ncbi.nlm.nih.gov/pubmed/31396213 http://dx.doi.org/10.3389/fimmu.2019.01659

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