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Opportunistic complexes of E. coli L-asparaginases with citrate anions

Active sites of enzymes are highly optimized for interactions with specific substrates, thus binding of opportunistic ligands is usually observed only in the absence of native substrates or products. However, during growth of crystals required for structure determination enzymes are often exposed to...

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Detalles Bibliográficos
Autores principales: Lubkowski, Jacek, Chan, Waikin, Wlodawer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667453/
https://www.ncbi.nlm.nih.gov/pubmed/31363102
http://dx.doi.org/10.1038/s41598-019-46432-0