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Opportunistic complexes of E. coli L-asparaginases with citrate anions
Active sites of enzymes are highly optimized for interactions with specific substrates, thus binding of opportunistic ligands is usually observed only in the absence of native substrates or products. However, during growth of crystals required for structure determination enzymes are often exposed to...
Autores principales: | Lubkowski, Jacek, Chan, Waikin, Wlodawer, Alexander |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667453/ https://www.ncbi.nlm.nih.gov/pubmed/31363102 http://dx.doi.org/10.1038/s41598-019-46432-0 |
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