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Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
Skeletal muscle insulin resistance, decreased phosphatidylinositol 3-kinase (PI3K) activation and altered mitochondrial function are hallmarks of type 2 diabetes. To determine the relationship between these abnormalities, we created mice with muscle-specific knockout of the p110α or p110β catalytic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667496/ https://www.ncbi.nlm.nih.gov/pubmed/31363081 http://dx.doi.org/10.1038/s41467-019-11265-y |