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Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism

Skeletal muscle insulin resistance, decreased phosphatidylinositol 3-kinase (PI3K) activation and altered mitochondrial function are hallmarks of type 2 diabetes. To determine the relationship between these abnormalities, we created mice with muscle-specific knockout of the p110α or p110β catalytic...

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Detalles Bibliográficos
Autores principales:	Li, Mengyao Ella, Lauritzen, Hans P. M. M., O’Neill, Brian T., Wang, Chih-Hao, Cai, Weikang, Brandao, Bruna B., Sakaguchi, Masaji, Tao, Rongya, Hirshman, Michael F., Softic, Samir, Kahn, C. Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667496/ https://www.ncbi.nlm.nih.gov/pubmed/31363081 http://dx.doi.org/10.1038/s41467-019-11265-y

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