Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122

Hepatitis C virus (HCV) harnesses host dependencies to infect human hepatocytes. We previously identified a pivotal role of IκB kinase α (IKK-α) in regulating cellular lipogenesis and HCV assembly. In this study, we defined and characterized NF-κB-inducing kinase (NIK) as an IKK-α upstream serine/th...

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Detalles Bibliográficos
Autores principales: Lowey, Brianna, Hertz, Laura, Chiu, Stephan, Valdez, Kristin, Li, Qisheng, Liang, T. Jake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667626/
https://www.ncbi.nlm.nih.gov/pubmed/31363036
http://dx.doi.org/10.1128/mBio.01617-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667626/
https://www.ncbi.nlm.nih.gov/pubmed/31363036
http://dx.doi.org/10.1128/mBio.01617-19

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