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Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis

Relaxin family peptide 1 (RXFP1) is the receptor for relaxin a peptide hormone with important therapeutic potential. Like many G protein‐coupled receptors (GPCRs), RXFP1 has been reported to form homodimers. Given the complex activation mechanism of RXFP1 by relaxin, we wondered whether homodimeriza...

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Detalles Bibliográficos
Autores principales: Hoare, Bradley L., Kocan, Martina, Bruell, Shoni, Scott, Daniel J., Bathgate, Ross A. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667744/
https://www.ncbi.nlm.nih.gov/pubmed/31384473
http://dx.doi.org/10.1002/prp2.513