A PD-L1-Based Cancer Vaccine Elicits Antitumor Immunity in a Mouse Melanoma Model

Engagement of programmed death 1 receptor (PD-1) and its ligand PD-L1/2 induces a signal transduction pathway that inhibits the activity of tumor-infiltrating cytotoxic T lymphocytes and promotes tumor growth and metastasis. Antibodies blocking PD-1 or PD-L1 can restore antitumor T cell responses an...

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Detalles Bibliográficos
Autores principales: Lin, Zhibing, Zhang, Yan, Cai, Huaman, Zhou, Fuqiang, Gao, Hongjun, Deng, Li, Li, Rongxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667823/
https://www.ncbi.nlm.nih.gov/pubmed/31384666
http://dx.doi.org/10.1016/j.omto.2019.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667823/
https://www.ncbi.nlm.nih.gov/pubmed/31384666
http://dx.doi.org/10.1016/j.omto.2019.06.002

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