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A protocol to transfer a fed‐batch platform process into semi‐perfusion mode: The benefit of automated small‐scale bioreactors compared to shake flasks as scale‐down model

Continuous processes such as perfusion processes can offer advantages compared to fed‐batch or batch processes in bio‐processing: improved product quality (e.g. for labile products), increased product yield, and cost savings. In this work, a semi‐perfusion process was established in shake flasks and...

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Detalles Bibliográficos
Autores principales: Janoschek, Sabrina, Schulze, Markus, Zijlstra, Gerben, Greller, Gerhard, Matuszczyk, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667907/
https://www.ncbi.nlm.nih.gov/pubmed/30479066
http://dx.doi.org/10.1002/btpr.2757