Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

OBJECTIVE: To compare DNA methylation in subjects positive vs negative for anti-citrullinated protein antibodies (ACPA), a key serological marker of rheumatoid arthritis (RA) risk. METHODS: With banked serum from a random subset (N = 3600) of a large general population cohort, we identified ACPA-pos...

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Detalles Bibliográficos
Autores principales: Shao, Xiaojian, Hudson, Marie, Colmegna, Ines, Greenwood, Celia M. T., Fritzler, Marvin J., Awadalla, Philip, Pastinen, Tomi, Bernatsky, Sasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668183/
https://www.ncbi.nlm.nih.gov/pubmed/31366403
http://dx.doi.org/10.1186/s13148-019-0699-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668183/
https://www.ncbi.nlm.nih.gov/pubmed/31366403
http://dx.doi.org/10.1186/s13148-019-0699-9

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