Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin

Sickle cell disease is a genetic blood disorder caused by a single point mutation in the β globin gene where glutamic acid is replaced by valine at the sixth position of the β chain of hemoglobin (Hb). At low oxygen tension, the polymerization of deoxyHbS into fibers occurs in red blood cells (RBCs)...

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Detalles Bibliográficos
Autores principales: Kassa, Tigist, Wood, Francine, Strader, Michael Brad, Alayash, Abdu I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668304/
https://www.ncbi.nlm.nih.gov/pubmed/31396101
http://dx.doi.org/10.3389/fphys.2019.00931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668304/
https://www.ncbi.nlm.nih.gov/pubmed/31396101
http://dx.doi.org/10.3389/fphys.2019.00931

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