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Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin

Sickle cell disease is a genetic blood disorder caused by a single point mutation in the β globin gene where glutamic acid is replaced by valine at the sixth position of the β chain of hemoglobin (Hb). At low oxygen tension, the polymerization of deoxyHbS into fibers occurs in red blood cells (RBCs)...

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Detalles Bibliográficos
Autores principales:	Kassa, Tigist, Wood, Francine, Strader, Michael Brad, Alayash, Abdu I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668304/ https://www.ncbi.nlm.nih.gov/pubmed/31396101 http://dx.doi.org/10.3389/fphys.2019.00931

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