Targeted Promoter Replacement Reveals That Herpes Simplex Virus Type-1 and 2 Specific VP16 Promoters Direct Distinct Rates of Entry Into the Lytic Program in Sensory Neurons in vivo

Infection and life-long residence in the human nervous system is central to herpes simplex virus (HSV) pathogenesis. Access is gained through innervating axonal projections of sensory neurons. This distinct mode of entry separates the viral genome from tegument proteins, including the potent transac...

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Detalles Bibliográficos
Autores principales: Thompson, Richard L., Sawtell, Nancy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668326/
https://www.ncbi.nlm.nih.gov/pubmed/31396171
http://dx.doi.org/10.3389/fmicb.2019.01624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668326/
https://www.ncbi.nlm.nih.gov/pubmed/31396171
http://dx.doi.org/10.3389/fmicb.2019.01624

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