A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode

Human dihydroorotate dehydrogenase (DHODH), the enzyme that catalyzes the rate‐limiting step in de novo pyrimidine biosynthesis, is considered to be an attractive target for potential treatment of autoimmune disease and cancer. Here, we present a novel class of human DHODH inhibitors with high inhib...

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Detalles Bibliográficos
Autores principales: Zeng, Ting, Zuo, Zeping, Luo, Youfu, Zhao, Yinglan, Yu, Yamei, Chen, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668370/
https://www.ncbi.nlm.nih.gov/pubmed/31087527
http://dx.doi.org/10.1002/2211-5463.12658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668370/
https://www.ncbi.nlm.nih.gov/pubmed/31087527
http://dx.doi.org/10.1002/2211-5463.12658

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