(1)H NMR-MS-based heterocovariance as a drug discovery tool for fishing bioactive compounds out of a complex mixture of structural analogues

Chemometric methods and correlation of spectroscopic or spectrometric data with bioactivity results are known to improve dereplication in classical bio-guided isolation approaches. However, in drug discovery from natural sources the isolation of bioactive constituents from a crude extract containing...

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Detalles Bibliográficos
Autores principales: Grienke, Ulrike, Foster, Paul A., Zwirchmayr, Julia, Tahir, Ammar, Rollinger, Judith M., Mikros, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668471/
https://www.ncbi.nlm.nih.gov/pubmed/31366964
http://dx.doi.org/10.1038/s41598-019-47434-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668471/
https://www.ncbi.nlm.nih.gov/pubmed/31366964
http://dx.doi.org/10.1038/s41598-019-47434-8

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