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Immunometabolic Dysfunction of Natural Killer Cells Mediated by the Hypoxia-CD73 Axis in Solid Tumors
NK cell infiltration into solid tumors is often low and is largely represented by the poorly-cytotoxic CD56(bright) subset. Numerous studies have demonstrated that CD73, overexpressed under conditions of hypoxia, is involved in a variety of physiological processes, while its overexpression has been...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668567/ https://www.ncbi.nlm.nih.gov/pubmed/31396523 http://dx.doi.org/10.3389/fmolb.2019.00060 |