Structural basis for broad substrate specificity of UDP-glucose 4-epimerase in the human milk oligosaccharide catabolic pathway of Bifidobacterium longum

Infant gut-associated bifidobacteria has a metabolic pathway that specifically utilizes lacto-N-biose I (Gal-β1,3-GlcNAc) and galacto-N-biose (Gal-β1,3-GalNAc) from human milk and mucin glycans. UDP-glucose 4-epimerase (GalE) from Bifidobacterium longum (bGalE) catalyzes epimerization reactions of U...

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Detalles Bibliográficos
Autores principales: Nam, Young-Woo, Nishimoto, Mamoru, Arakawa, Takatoshi, Kitaoka, Motomitsu, Fushinobu, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668579/
https://www.ncbi.nlm.nih.gov/pubmed/31366978
http://dx.doi.org/10.1038/s41598-019-47591-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668579/
https://www.ncbi.nlm.nih.gov/pubmed/31366978
http://dx.doi.org/10.1038/s41598-019-47591-w

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