Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colon carcinoma HCT116 cells mediated by JNK/p38/ERK1/2 via a p53-independent signaling

Ru(II)-thymine complex [Ru(PPh(3))(2)(Thy)(bipy)]PF(6) (where PPh(3) = triphenylphosphine, Thy = thyminate and bipy = 2,2′-bipyridine) is a potent cytotoxic agent with ability to bind to DNA, inducing caspase-mediated apoptosis in leukemia cells. In this study, we investigated the mechanism underlyi...

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Detalles Bibliográficos
Autores principales: Silva, Suellen L. R., Baliza, Ingrid R. S., Dias, Rosane B., Sales, Caroline B. S., Rocha, Clarissa A. Gurgel, Soares, Milena B. P., Correa, Rodrigo S., Batista, Alzir A., Bezerra, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668648/
https://www.ncbi.nlm.nih.gov/pubmed/31366902
http://dx.doi.org/10.1038/s41598-019-47539-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668648/
https://www.ncbi.nlm.nih.gov/pubmed/31366902
http://dx.doi.org/10.1038/s41598-019-47539-0

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