Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer

The presence of tumor-infiltrating T cells is associated with favorable patient outcomes, yet most pancreatic cancers are immunologically silent and resistant to currently available immunotherapies. Here we show using a syngeneic orthotopic implantation model of pancreatic cancer that Pik3ca regulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Sivaram, Nithya, McLaughlin, Patrick A., Han, Han V., Petrenko, Oleksi, Jiang, Ya-Ping, Ballou, Lisa M., Pham, Kien, Liu, Chen, van der Velden, Adrianus W.M., Lin, Richard Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668699/
https://www.ncbi.nlm.nih.gov/pubmed/31112530
http://dx.doi.org/10.1172/JCI123540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668699/
https://www.ncbi.nlm.nih.gov/pubmed/31112530
http://dx.doi.org/10.1172/JCI123540

Ejemplares similares