Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain

Signaling through the receptor tyrosine kinase RET is essential during normal development. Both gain- and loss-of-function mutations are involved in a variety of diseases, yet the molecular details of receptor activation have remained elusive. We have reconstituted the complete extracellular region...

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Detalles Bibliográficos
Autores principales: Bigalke, Janna M., Aibara, Shintaro, Roth, Robert, Dahl, Göran, Gordon, Euan, Dorbéus, Sarah, Amunts, A., Sandmark, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669014/
https://www.ncbi.nlm.nih.gov/pubmed/31392261
http://dx.doi.org/10.1126/sciadv.aau4202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669014/
https://www.ncbi.nlm.nih.gov/pubmed/31392261
http://dx.doi.org/10.1126/sciadv.aau4202

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