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Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain
Signaling through the receptor tyrosine kinase RET is essential during normal development. Both gain- and loss-of-function mutations are involved in a variety of diseases, yet the molecular details of receptor activation have remained elusive. We have reconstituted the complete extracellular region...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669014/ https://www.ncbi.nlm.nih.gov/pubmed/31392261 http://dx.doi.org/10.1126/sciadv.aau4202 |