RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of P57

RUNX1 is a key transcription factor in hematopoiesis and its disruption is one of the most common aberrations in acute myeloid leukemia. RUNX1 alterations affect its DNA binding capacity and transcriptional activities, leading to the deregulation of transcriptional targets, and abnormal proliferatio...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Xing, Yanyan, Lu, Wenting, Li, Shouyun, Tian, Zheng, Xing, Haiyan, Tang, Kejing, Xu, Yingxi, Rao, Qing, Wang, Min, Wang, Jianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669147/
https://www.ncbi.nlm.nih.gov/pubmed/30792202
http://dx.doi.org/10.3324/haematol.2018.192773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669147/
https://www.ncbi.nlm.nih.gov/pubmed/30792202
http://dx.doi.org/10.3324/haematol.2018.192773

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