Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors

Entry of HIV-1 into target cells is mediated by its envelope (Env) glycoprotein composed of the receptor binding subunit gp120 and the fusion protein gp41. Refolding of the gp41 N- and C-terminal heptad repeats (NHR and CHR) into a six-helix bundle (6-HB) conformation drives the viral and cellular m...

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Detalles Bibliográficos
Autores principales: Geng, Xiuzhu, Liu, Zixuan, Yu, Danwei, Qin, Bo, Zhu, Yuanmei, Cui, Sheng, Chong, Huihui, He, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669600/
https://www.ncbi.nlm.nih.gov/pubmed/31277353
http://dx.doi.org/10.3390/v11070609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669600/
https://www.ncbi.nlm.nih.gov/pubmed/31277353
http://dx.doi.org/10.3390/v11070609

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