Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo

Human adenovirus 5 (HAdV-5) is used as a vector in gene therapy clinical trials, hence its interactions with the host immune system have been widely studied. Previous studies have demonstrated that HAdV-5 binds specifically to murine coagulation factor X (mFX), inhibiting IgM and complement-mediated...

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Detalles Bibliográficos
Autores principales: Doszpoly, Andor, de la Cuesta, Fernando, Lopez-Gordo, Estrella, Bénézech, Cécile, Nicklin, Stuart A., Baker, Andrew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669743/
https://www.ncbi.nlm.nih.gov/pubmed/31284434
http://dx.doi.org/10.3390/v11070616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669743/
https://www.ncbi.nlm.nih.gov/pubmed/31284434
http://dx.doi.org/10.3390/v11070616

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