Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Nuclear protein aggregation has been linked to genome instability and disease. The main source of aggregation‐prone proteins in cells is defective ribosomal products (DRiPs), which are generated by translating ribosomes in the cytoplasm. Here, we report that DRiPs rapidly diffuse into the nucleus an...

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Detalles Bibliográficos
Autores principales: Mediani, Laura, Guillén‐Boixet, Jordina, Vinet, Jonathan, Franzmann, Titus M, Bigi, Ilaria, Mateju, Daniel, Carrà, Arianna D, Morelli, Federica F, Tiago, Tatiana, Poser, Ina, Alberti, Simon, Carra, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669919/
https://www.ncbi.nlm.nih.gov/pubmed/31271238
http://dx.doi.org/10.15252/embj.2018101341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669919/
https://www.ncbi.nlm.nih.gov/pubmed/31271238
http://dx.doi.org/10.15252/embj.2018101341

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