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Identification of a basal system for unwinding a bacterial chromosome origin

Genome duplication is essential for cell proliferation, and DNA synthesis is generally initiated by dedicated replication proteins at specific loci termed origins. In bacteria, the master initiator DnaA binds the chromosome origin (oriC) and unwinds the DNA duplex to permit helicase loading. However...

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Detalles Bibliográficos
Autores principales: Richardson, Tomas T, Stevens, Daniel, Pelliciari, Simone, Harran, Omar, Sperlea, Theodor, Murray, Heath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669920/
https://www.ncbi.nlm.nih.gov/pubmed/31267560
http://dx.doi.org/10.15252/embj.2019101649