MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites

Unresolved endoplasmic reticulum (ER) stress shifts the unfolded protein response signaling from cell survival to cell death, although the switching mechanism remains unclear. Here, we report that mitochondrial ubiquitin ligase (MITOL/MARCH5) inhibits ER stress‐induced apoptosis through ubiquitylati...

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Detalles Bibliográficos
Autores principales: Takeda, Keisuke, Nagashima, Shun, Shiiba, Isshin, Uda, Aoi, Tokuyama, Takeshi, Ito, Naoki, Fukuda, Toshifumi, Matsushita, Nobuko, Ishido, Satoshi, Iwawaki, Takao, Uehara, Takashi, Inatome, Ryoko, Yanagi, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669929/
https://www.ncbi.nlm.nih.gov/pubmed/31368599
http://dx.doi.org/10.15252/embj.2018100999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669929/
https://www.ncbi.nlm.nih.gov/pubmed/31368599
http://dx.doi.org/10.15252/embj.2018100999

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