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Regioisomer-independent quantification of fatty acid oxidation products by HPLC-ESI-MS/MS analysis of sodium adducts

Despite growing acknowledgement of the role of oxidized fatty acids (oxFA) as cellular signaling molecules and in the pathogenesis of disease, developing methods to measure these species in biological samples has proven challenging. Here we describe a novel method utilizing HPLC-ESI-MS/MS to identif...

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Detalles Bibliográficos
Autores principales: Ahern, Katelyn W., Serbulea, Vlad, Wingrove, Catherine L., Palas, Zachary T., Leitinger, Norbert, Harris, Thurl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671977/
https://www.ncbi.nlm.nih.gov/pubmed/31371760
http://dx.doi.org/10.1038/s41598-019-47693-5