ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently established that in vivo apoC-III predomin...

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Detalles Bibliográficos
Autores principales: Ramms, Bastian, Patel, Sohan, Nora, Chelsea, Pessentheiner, Ariane R., Chang, Max W., Green, Courtney R., Golden, Gregory J., Secrest, Patrick, Krauss, Ronald M., Metallo, Christian M., Benner, Christopher, Alexander, Veronica J., Witztum, Joseph L., Tsimikas, Sotirios, Esko, Jeffrey D., Gordts, Philip L. S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672034/
https://www.ncbi.nlm.nih.gov/pubmed/31092690
http://dx.doi.org/10.1194/jlr.M093740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672034/
https://www.ncbi.nlm.nih.gov/pubmed/31092690
http://dx.doi.org/10.1194/jlr.M093740

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