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Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease
A central challenge in human genomics is to understand the cellular, evolutionary, and clinical significance of genetic variants. Here, we introduce a unified population-genetic and machine-learning model, called Linear Allele-Specific Selection InferencE (LASSIE), for estimating the fitness effects...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673719/ https://www.ncbi.nlm.nih.gov/pubmed/31249063 http://dx.doi.org/10.1101/gr.245522.118 |