Aberrant DNA methylation defines isoform usage in cancer, with functional implications

Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression include somatic mutations in splice regulatory sites or altered splicing factors. However, since DNA methylation is known to regulate transcriptional isoform...

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Detalles Bibliográficos
Autores principales: Chen, Yun-Ching, Elnitski, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675117/
https://www.ncbi.nlm.nih.gov/pubmed/31329578
http://dx.doi.org/10.1371/journal.pcbi.1007095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675117/
https://www.ncbi.nlm.nih.gov/pubmed/31329578
http://dx.doi.org/10.1371/journal.pcbi.1007095

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