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Aberrant DNA methylation defines isoform usage in cancer, with functional implications
Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression include somatic mutations in splice regulatory sites or altered splicing factors. However, since DNA methylation is known to regulate transcriptional isoform...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675117/ https://www.ncbi.nlm.nih.gov/pubmed/31329578 http://dx.doi.org/10.1371/journal.pcbi.1007095 |