NTCP deficiency in mice protects against obesity and hepatosteatosis

Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na(+) taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. Reducing hepatic clearance of bile acids fr...

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Detalles Bibliográficos
Autores principales: Donkers, Joanne M., Kooijman, Sander, Slijepcevic, Davor, Kunst, Roni F., Roscam Abbing, Reinout L.P., Haazen, Lizette, de Waart, Dirk R., Levels, Johannes H.M., Schoonjans, Kristina, Rensen, Patrick C.N., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675549/
https://www.ncbi.nlm.nih.gov/pubmed/31237863
http://dx.doi.org/10.1172/jci.insight.127197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675549/
https://www.ncbi.nlm.nih.gov/pubmed/31237863
http://dx.doi.org/10.1172/jci.insight.127197

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